Hemolysis, Pulmonary Hypertension, Thalassemia in Children
Conditions
Keywords
Thalassemia, Glutamine/glutamate ratio, Pulmonary hypertension
Brief summary
The study will investigate the relation between erythrocyte glutamine/glutamate ratio and pulmonary hypertension risk in Egyptian thalassemic children in Assiut University Children Hospital
Interventions
DIAGNOSTIC_TESTblood sample
blood sample for measuring liver and kidney function, CBC, ferritin level and erythrocyte glutamine level
DIAGNOSTIC_TESTTricuspid regurge velocity
Tricuspid regurge velocity will be measured by doppler echocardiography denoting the pulmonary hypertension risk in children
Sponsors
Assiut University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
10 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* Established diagnosis of Thalassemia. * PH risk documented by doppler echocardiography, defined as tricuspid regurge velocity (TRV) equal to or greater than 2.5 m/s
Exclusion criteria
* Acute crisis or hospitalization within 1 month of enrollment * Hepatic dysfunction (SGPT greater than 3X normal) * Renal dysfunction (Creatinine greater than 2X normal) * Patients on sildenafil (Viagra), calcium channel blockers or other drugs for the control of PH.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Erythrocyte glutamine level | 2 months | marker for oxidative stress |
| Tricuspid regurge velocity | 2 months | Measures the risk of pulmonary hypertension |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Plasma glutamine level | 2 months | Assess the glutamine level at each visit |
| Liver function tests | 2 months | Evaluates the state of liver |
| Renal function tests | 2 months | Evaluates the state of kidney |
| Ferritin level | 2 months | measuring the iron overload |
Countries
Egypt
Outcome results
None listed