Emergence Delirium
Conditions
Brief summary
Evaluation of prevention of emergence delirium and analgesic effect of magnesium on children
Detailed description
Children \< 8 years old who scheduled for elective opthalmic surgery are randomly assigned to Magnesium (Mg) group and control group. Before anesthetic induction, modified Yale Preoperative Anxiety Scale (m-YPAS) is assessed. Routine anesthetic induction is performed, and neuromuscular blocker is not used. Laryngeal mask airway is inserted and controlled ventilation is started. In Mg group, Mg of 30 mg/kg is administered for 10 minutes and then continuously infused (10mg/kg/hr) until 5 minutes before surgery end. In control group, the similar volume of saline is infused. Pediatric Anesthesia Emergence Delirium (PAED) scale and pain score (Modified Children's Hospital of Eastern Ontario Pain Scale, CHEOPS) will be measured immediately after and 30 minutes after surgery.
Interventions
DRUGMagnesium
Mg is administered during anesthesia until 5 minutes before surgery ends
DRUGSaline
Same volume of saline is infused until 5 minutes before surgery ends
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
2 Years to 7 Years
Healthy volunteers
Yes
Inclusion criteria
* Children aged between 2 and 7 years * American Society of Anesthesiologist physical status 1 and 2 * Children scheduled for opthalmic surgery
Exclusion criteria
* Allergy history to any drugs * Risk of malignant hyperthermia * Neuromuscular disease * With arrhythmia * Any pulmonary, cardiac, hepatic and renal disease * Obesity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Emergence delirium | 30 minutes after anesthesia | Pediatric Anesthesia Emergence Delirium (PAED) scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain score | At each two points: during emergence in operating room and 30 minutes after surgery ends | Modified Children's Hospital of Eastern Ontario Pain Scale, CHEOPS) |
| Nausea | At each two points: during emergence in operating room and 30 minutes after surgery ends | visual analogue scale |
| vomiting | At each two points: during emergence in operating room and 30 minutes after surgery ends | number |
| Duration of post-anesthetic care unit (PACU) stay | During 1 hour after surgery at PACU | Duration of post-anesthetic care unit (PACU) stay |
Countries
South Korea
Outcome results
None listed