Anastomotic Leak, Ovarian Neoplasms Malignant
Conditions
Brief summary
EDMOCS trial pretends to evaluate if C-reactive protein (CRP) and procalcitonin (PCT) can predict intestinal anastomotic leaks before early discharge in advanced ovarian cancer surgery requiring intestinal resection. These markers have already been positively tested in colorectal cancer surgery, but not yet in ovarian surgery. Patients undergoing intestinal resection in ovarian cancer surgery will be included. C-reactive protein and PCT will be measured pre-operatively, and on the second, fourth and sixth postoperative day. Thirty-day readmissions, re-operations and mortality will be recorded.
Interventions
DIAGNOSTIC_TESTBlood test
C-reactive protein and PCT measured preoperatively, and on the second, fourth and sixth postoperative days.
Sponsors
Hospital Universitari Vall d'Hebron Research Institute
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Ovarian cancer stage III-IV * Intestinal resection needed
Exclusion criteria
* Infection diagnosed at time of surgery. * Urgent surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients with anastomotic leak detected by elevation of C-reactive protein and procalcitonin levels | Within the first 30 days after the surgery | To evaluate whether C-reactive protein (CRP) and procalcitonin (PCT) can predict anastomotic leak before early discharge. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| C-reactive protein and procalcitonin measures in patients without complications in ovarian surgery. | Within the first six days after the surgery | Defining normal range values of C-Reactive Protein and Procalcitonin during postoperative ovarian cancer surgery. |
Countries
Spain
Outcome results
None listed