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Zinc and Iron in Children With Short Stature

Zinc and Iron in Children With Short Stature

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03131349
Acronym
zincandiron
Enrollment
50
Registered
2017-04-27
Start date
2017-06-01
Completion date
2019-08-15
Last updated
2020-10-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Zinc; Deficiency With Anemia

Brief summary

Short stature is defined as height below 3rd centile or less than two standard deviations below the median height for that age and sex according to the population standard zinc and iron have important role in growth for children

Detailed description

Short stature is defined as height below 3rd centile or less than two standard deviations below the median height for that age and sex according to the population standard. Approximately 3% children in any population will be short, amongst which half will be physiological (familial or constitutional) and half will be pathological. It is estimated that approximately 60%-80% of all short children at or below 2standerd deviation fit the definition of idiopathic short stature. The growth and development of human require an adequate supply of many different nutritional factors. Nutritional deficiencies causing short stature include: those associated with stunting as: protein and zinc, nutrient associated with rickts as :vitamin D, and those with bone abnormalities as: cupper,zin,and vitamin c Insufficient nutrition tends to lead to short stature with a delayed pattern of growth. Under-nutrition can be isolated (eg, caused by inadequate food supply or self-imposed restriction, such as fear of obesity), or it may be a component of an underlying systemic disease that interferes with food intake or absorption, or increases energy needs. The hallmark of under-nutrition is low weight-for-height . Trace elements are dietary mineral that are present in very minute quantities (less than 0.01%),they divided into three groups (WHO classification): Essential elements such as iodine and zinc ,Probably essential elements such as manganese and silicon , Potentially toxic elements such as fluoride,lead,cadmium, mercury, & Lithium. Trace elements play significant functions as growth,oregulation of gene expression, immunity,the endocrine system, brain development, and the cell protection system. An adequate micronutrient intake is crucial for health, particularly in infants, children and adolescents ,deficiency in micronutrients can affect growth and development, particularly during periods of rapid growth.

Interventions

DIAGNOSTIC_TESTserum zinc and iron

history ,examination,investigations

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
2 Years to 18 Years
Healthy volunteers
Yes

Inclusion criteria

* • children of both sexes. * Age range: 4-18 years. * patients fulfilling criteria of short stature. * height is 2 standard deviations below normal . * initial height below the third percentile on Egyptian growth chart. • Number of patients: will include 50 cases

Exclusion criteria

* Skeletal dysplasia. * Chromosomal anomalies

Design outcomes

Primary

MeasureTime frameDescription
zinc and iron in children with idiopathic short stature6 monthsAssessment of the serum level of zinc and iron in idiopathic with short stature.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026