Healthy
Conditions
Brief summary
This study is designed to determine the neural networks underlying the sleep-related motor consolidation process following motor imagery practice. While beneficial effects of sleep are expected for sequential movement but not for adaptation motor tasks, the corresponding neuroanatomical correlates have not yet been investigated when participants acquired the motor tasks through mental practice. Data should substantially promote how designing motor imagery interventions targeting (re)learning and/or motor recovery in patients suffering from motor disorders.
Interventions
OTHERImagery and Sleep questionnaires
Participants complete a motor imagery questionnaire to assess their ability to form vivid mental images, as well as sleep questionnaires to control the quality of their sleep
OTHERMEG recordings (pre-test)
Participants of the Day group perform two motor tasks (a finger sequential motor task and an adaptation motor task using a trackball) in the MEG, during a pre-test (Day 1 - 9h). Task 1: Participants perform an 8-digit motor sequential task where each finger (except the thumb) is used twice. Performance is assessed by using a 4-keys keyboard. Participants are required to keep their fingers on the keys to minimize amplitude are instructed to tap the sequence as few errors as possible Task 2: Participants perform a motor adaptation task requiring scrolling a trackball to superimpose a geometric shape on another one, strictly similar but presented from another angle, as fast as possible.
OTHERPractice session
Participants of the Day group perform a block of motor imagery practice of the two motor tasks.
OTHERMEG recordings (Post-test)
Participants perform the two motor tasks in the MEG (post-test, strictly similar to the pre-test)
OTHERMRI
The registration of the brain anatomy of each participant will be done by MRI 3D / T the week before the first experimental session.
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy right-handed persons without neurologic disease * Persons having signed informed consent for a neuroimagery study
Exclusion criteria
* Persons under curatorship or any administrative/judicial measure * Participants refusing to be informed of the results of the experiment * Pregnant women * Participants with contraindications to the MEG examination: head size, presence of a neurostimulator, steel pivot for the root canal, metallic fragments, ear implants, metal screws in the body or mouth. * Persons using a pacemaker, insulin pump, or working regularly with iron filings * Claustrophobic persons
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evidence of MEG correlates of sleep motor consolidation (day 1) | Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4) | The investigator will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions. |
| Evidence of MEG correlates of sleep motor consolidation (day 2) | Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4) | The investigator will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Accuracy of the motor tasks | Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4) | The investigators will measure the number of errors and correct trials for each motor task (finger sequential tasks OR motor adaptation task). |
| Time needed to complete the motor tasks (day 1) | Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4) | The investigators will measure the time needed to complete the motor tasks needed to complete each motor task (finger sequential tasks OR motor adaptation task). |
| Accuracy of the motor tasks 2 | Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4) | The investigators will measure the number of errors and correct trials for each motor task (finger sequential tasks OR motor adaptation task). |
| Time needed to complete the motor tasks | Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4) | The investigators will measure the time needed to complete each motor task (finger sequential tasks OR motor adaptation task). |
| Evidence of MEG correlates of sleep motor consolidation | Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4) | The investigators will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions. |
Countries
France
Outcome results
None listed