Predictive Value of β2-microspheres for Postoperative Delirium

The Predictive Value of β2-microspheres for Postoperative Delirium in the Elderly After Orthopedic Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03130231

Enrollment

184

Registered

2017-04-26

Start date

2015-10-01

Completion date

2017-12-30

Last updated

2018-12-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Delirium

Keywords

Delirium β2-microspheres

Brief summary

This study evaluated the predictive value of β2-microspheres for postoperative delirium (POD) in the elderly after orthopedic surgery. For this purpose, the levels of β2-microspheres in plasma and cerebrospinal fluid were compared between the POD and non-POD groups.

Detailed description

In this study, plasma and cerebrospinal fluid of the patients were collected to detect the levels of β2-microspheres before operation. Also, the patients were interviewed one day before the surgery and on postoperative days 1-3 by the Confusion Assessment Method and then divided them into POD and non-POD groups. The aim of the present study was to assess whether higher levels of β2-microspheres could predict the occurrence of POD.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* ≥65 years old, American Standards AssociationⅠ-Ⅲ, undergoing orthopedic operations under spinal anesthesia

Exclusion criteria

* decline to participate

Design outcomes

Primary

Measure	Time frame	Description
The incidence of POD	4 days	The patients were interviewed one day before the surgery and on postoperative days 1-3 by the Confusion Assessment Method and then divided them into POD and non-POD groups.

Secondary

Measure	Time frame	Description
The levels of β2-microspheres in plasma and cerebrospinal fluid	1 day	Before surgery, plasma and cerebrospinal fluid of the patients were collected to detect the levels of β2-microspheres.

Countries

China

Outcome results