Topical Analgesic Versus Saline Mouth Rinses in Post Extraction Healing

Comparison of Topical Analgesic With Saline Rinses in Post Extraction Healing Among Hypertensive and Non-Hypertensive Patients

Status

Completed

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03130153

Enrollment

Registered

2017-04-26

Start date

2016-01-01

Completion date

2017-12-31

Last updated

2018-06-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tooth Extraction Site Healing

Brief summary

There is no evidence based guidelines on using saline rinses for post extraction oral care among hypertensives. Similarly, benefit of orally dissolved topical analgesics in addition to orally administered analgesic is questionable.

Detailed description

Objective: To compare the post dental extraction healing among subjects who took simple analgesic tablets dissolved in water versus those who used saline rinses post operatively. Methods: A study will be done among patients who underwent dental extractions at AKHSP dental clinic, Karachi, Pakistan. Carious, periodontally mobile, traumatized or broken down teeth among 20-70 years old in either gender will be included. In addition to the routine prescription of antibiotics and oral analgesics, the hypertensive subjects (n=20) will be advised to take dissolved Aspirin tablet as an oral care while non-hypertensive will be divided into two sub groups (n=20 each), advised saline mouth rinses or dissolved Aspirin for 5 days, respectively. The outcome (healing of the extraction socket) will be evaluated 7 days from the day of extraction on an ordinal scale.

Interventions

DRUGAspirin Powder

Aspirin powder to be dissolved in water and to be used as mouthwash twice daily for 7 days after tooth extraction.

DRUGNormal saline

Normal saline to be used as mouthwash twice daily for 7 days after tooth extraction among non-hypertensive subjects.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Carious, periodontally mobile, traumatized or broken down teeth needing extraction * Age 20-70 years, both genders

Exclusion criteria

* Diabetes * Osteoporosis, metabolic bone disease etc. * Radiation therapy or chemotherapy.

Design outcomes

Primary

Measure	Time frame	Description
Healing of the extraction socket	Seven days from the day of extraction	1. = healed or healing well 2. = incomplete healing but progressing 3. = poorly healed open margins and readily bleeding

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026