Diaphragm
Conditions
Brief summary
This study is investigating the normal range of maximal diaphragm thickness during a sniff inspiratory manoeuvre using ultrasound in healthy subjects stratified by age and gender.
Detailed description
Diaphragm dysfunction is associated with poor clinical outcomes in critically ill patients but is difficult to diagnose. Traditionally, diaphragm function is measured by evaluating inspiratory muscle strength via maximal inspiratory pressure (MIP). However, this technique relies on a volitional maximal effort and can be challenging for patients to perform. An alternative to measuring inspiratory muscle strength is the sniff inspiratory pressure approach. During short, sharp sniffs, the diaphragm is maximally activated. Currently, there are no reported values of the normal range of maximal diaphragm thickness during a sniff maneuver. This study will define the normal range of values for sniff maximal diaphragm thickening fraction, maximal thickening against an occluded airway, and diaphragm thickening during resting tidal breathing in healthy subjects.
Interventions
None listed
Sponsors
University Health Network, Toronto
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Over 18 years of age
Exclusion criteria
* Antecedent history of neuromuscular or cardiorespiratory disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sniff diaphragm thickening fraction | Day 1 | Thickening of the diaphragm during an inspiratory sniff |
| Maximal diaphragm thickening fraction | Day 1 | Thickening of the diaphragm during a maximal inspiratory effort |
| Resting tidal thickening fraction | Day 1 | Thickening of the diaphragm during resting tidal breathing |
Countries
Canada
Contacts
PRINCIPAL_INVESTIGATOREwan C Goligher, MD, PhD
University Health Network, Toronto
Outcome results
None listed