Adductor Spasmodic Dysphonia
Conditions
Brief summary
This study will compare the effects of vocal rest versus continuous vocalization for one hour immediately following botulinum toxin injections for adductor spasmodic dysphonia.
Interventions
BEHAVIORALVocal rest versus vocalization
A comparison of one hour of vocal rest versus continuous vocalization after botulinum toxin injection
Sponsors
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Intervention model description
The proposed study is a randomized, cross-over, clinical trial involving the comparison of two treatments (A and B) separated by a wash-out period (W). The patient participants will be randomized to one of the following two treatment orders: AWB or BWA.
Eligibility
Sex/Gender
ALL
Age
21 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosed with adductor spasmodic dysphonia (ADSD) by an experienced neurologist and otolaryngologist. ADSD patients who have been stabilized on their treatment dose for at least 2 treatment cycles.
Exclusion criteria
* Diagnosed with another neurological disorder that is combined with ADSD (i.e. Parkinson's disease and ADSD). Previous history of an additional vocal pathology (i.e. vocal polps, vocal nodules, unilateral vocal fold paralysis, etc.)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Severity of spasmodic dysphonia symptoms | Six weeks post-treatment | Acoustic measures and perceptual ratings of vocal spasm severity |
| Patient-reported outcome measures of symptoms and communication | six weeks post-treatment | Six patient-reported questionnaires related to symptoms, communication effectiveness, quality of life, and self-efficacy |
Countries
Canada
Outcome results
None listed