Synchronizing Blastocyst in Frozen Embryo Transfer

Synchronizing Blastocyst at Hatching Stage in Frozen Embryo Transfer Cycles

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03128970

Enrollment

742

Registered

2017-04-25

Start date

2017-04-21

Completion date

2018-05-10

Last updated

2019-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Embryo Implantation

Brief summary

The aim of the present study is to determine if implantation rate could be increased in women undergoing frozen embryo transfer cycles in case of adjusting their embryo development at hatching stage.

Interventions

OTHERsynchronizing blastocysts

transferring frozen/thawed a synchronized blastocysts at hatching stage into female uterus.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

DOUBLE (Subject, Caregiver)

Masking description

The gynecologist performing the embryo transfer as well as the patients undergoing frozen embryo transfer will be blinded to group allocation

Eligibility

Sex/Gender

FEMALE

Age

19 Years to 33 Years

Healthy volunteers

Inclusion criteria

1. Patients who will agree to participate and assign an informed consent form 2. Only blastocyst transfer FET cycles 3. Patients undergoing FET after their 1st IVF or ICSI cycle with no pregnancy at the fresh transfer 4. Freeze-all cycles due to OHSS 5. Freeze-all cycles due to poor endometrium 6. Age 19-33 at the time of randomization. 7. Their frozen blastocysts are 3 or less grade of expansion. 8. Female with a ≥12 AFCs 9. Endometrial thickness ≥ 8mm at the time of ovulation 10. Women with their male partners will give only fresh semen 11. Women who have no uterine abnormality by ultrasound 12. BMI ≤ 31

Exclusion criteria

1. Cycles undergoing preimplantation genetic diagnosis. 2. Women who have previous two cycles of implantation failure at fresh transfer 3. Women who have previous two FET failed cycles 4. Any uterine pathology (myomas, adenomyosis, endocrinopathies, thrombophilia, chronic pathologies, acquired or congenital uterine abnormalities) 5. Patients with severe endometriosis 6. Presence of uni- or bilateral hydrosalpinx 7. Recurrent pregnancy loss. 8. Any medical condition that affect fertility.

Design outcomes

Primary

Measure	Time frame	Description
Ongoing implantation rate	12 weeks	ultrasound detection of ongoing gestational sacs with heartbeats after 12 weeks of gestation per transferred embryos

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026