Parkinson Disease
Conditions
Brief summary
Deep brain stimulation of the sub thalamic nucleus (STN-DBS) is an efficient treatment to improve motor and non motor signs of Parkinson's disease (PD). In people aged more 70 years, an increased rate of side effects such as post-operative cognitive decline and/or postural instability with falls has been suspected with less improvement in the quality of life. Here, Investigators aim further explore the effects of STN-DBS in 50 patients with PD people aged more 69 years in a randomized parallel controlled study.
Detailed description
The effects of combined bilateral deep brain stimulation of the subthalamic nucleus and medical treatment on the quality of life will be evaluated in 25 PD patients aged more 69 years in comparison to 25 PD patients aged more 69 years that only received medical drug treatment.
Interventions
Stimulation of the subthalamic nucleus
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
69 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Parkinson's disease * disease duration \> 5 years * levodopa related motor complications * dopasensitivity \> 50% * signed informed written consent * medical social insurance
Exclusion criteria
* dementia * contra-indication to neurosurgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PDQ-39 Quality of life questionnary | Quality of life one year after surgery | PDQ-39 : Parkinson's disease quality of life scale questionnaire with 39 questions, grouped into 8 domains. Each item is scored on a scale from 0 to 4, with higher scores indicating greater difficulties. An overall score can be calculated by averaging the eight domain scores. Scores range from 0 to 100 : 0 = best quality of life 100 = worst quality of life |
Countries
France
Outcome results
None listed