Healthy
Conditions
Keywords
Oxytocin, Resting-state, Functional connectivity, BOLD
Brief summary
To investigate whether 40 IU of intranasal oxytocin treatment can influence the resting-state functional connectivity in healthy males.
Detailed description
In a double-blind, between-subject, placebo controlled design, investigators plan to investigate the effects of oxytocin treatment on resting-state functional connectivity. Subject will receive either intranasal oxytocin or placebo administration and go through a seven-minute resting-state scan in MRI scanner to test whether oxytocin changes functional connectivity in the brain. Trait anxiety and mood questionnaires will be administered as control variables.
Interventions
DRUGOxytocin
Oxytocin, intranasally administrated
DRUGPlacebos
Saline, intranasally administrated
Sponsors
University of Electronic Science and Technology of China
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy subjects without past or current psychiatric or neurological disorders
Exclusion criteria
* with MRI Contraindications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Striatal functional connectivity alterations after drug administration | 45 minutes after drug administration | fMRI-based resting state connectivity of the striatum will be compared between the oxytocin and the placebo group |
Countries
China
Outcome results
None listed