Hypertension, Obstructive Sleep Apnea
Conditions
Keywords
nocturnal hypertension, non-dipping blood pressure, obstructive sleep apnea
Brief summary
The purpose of this study is to determine if high salt diet contributes to high nighttime blood pressure. The investigators will determine if high compared to low salt diet increases 24-hour blood pressure levels. The investigators will also determine if high salt diet affects blood vessel stiffness, cardiac output, and sleep apnea. The study will also determine how high salt diet affects the activity of certain genes related to control of blood pressure. A total of 60 participants will be enrolled in the study.
Interventions
DIETARY_SUPPLEMENTDietary sodium
High (6 g) versus low (1.5 g) sodium diet
Sponsors
American Heart Association
University of Alabama at Birmingham
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Masking description
Both the participant and investigator are blinded to the diet
Intervention model description
Crossover study of high (6 g) and low (1.5 g) sodium diet
Eligibility
Sex/Gender
ALL
Age
48 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Nocturnal hypertension
Exclusion criteria
* Stage 2 clinic hypertension * History of congestive heart failure * Chronic kidney disease, * Diabetes with insulin use * History of a cardiovascular event * Pregnant or nursing * Current use of continuous positive airway pressure * Shift work * A known circadian rhythm disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 24-hour blood pressure | Baseline to 7 days after start of dietary period | Blood pressure measured by an ambulatory blood pressure monitor |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Obstructive sleep apnea | Baseline to 7 days after start of dietary period | Severity of obstructive sleep apnea as determine by the apnea hypopnea index |
Countries
United States
Outcome results
None listed