Pre-Eclampsia
Conditions
Brief summary
The purpose of this study is to compare the sensitivity and the specificity of electrical cardiometry to the lung ultrasound in measuring thoracic lung water in pregnant females with pre-eclampsia. If electrical cardiometry is validated against ultrasound, it will be easy to use with numerical number that will not require advanced experience as with the ultrasound.
Detailed description
Pre-eclampsia is accompanied with increased risk of serious complications such as pulmonary edema, cerebrovascular accidents, coagulopathy, and hemorrhage. Pre-eclampsia is responsible for 46.6% of the etiology of acute pulmonary edema in pregnant women. Fluid management in pre-eclamptic patients is challenging. Hypovolemia exacerbates organ failure, whereas volume overload results in pulmonary edema. Thus, using different methods for evaluation of volume status of the patients would improve patient management. Lung ultrasound has been developed as an accurate non-invasive method for assessment of extra-vascular lung water; However, ultrasound needs skilled operator. Electrical velocimetry (cardiometry) is a newer technology for assessment of total thoracic fluid content (TFC); however, it has not been validated in pre-eclamptic patients. In this study the investigators will validate the accuracy of cardiometry in evaluation of lung water using the lung ultrasound as a gold standard. Both methods will be evaluated for prediction of the need of diuretic therapy and the need for post-operative oxygen therapy.
Interventions
None listed
Sponsors
Cairo University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* pregnant * pre-eclamptic * In first stage of labor
Exclusion criteria
* Eclampsia. * Second, third and fourth stages of labor on admission. * Patients with severe cardiac and/or pulmonary disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| total thoracic fluid content | after 30 minutes from patient admission to the obstetric casuality | total fluid content measured by electrical velocimetry device (cardiometry) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| extra-vascular lung water | after 30 minutes from patient admission to the obstetric casuality | extra-vascular lung water measured by ultrasound (lung ultrasound score) |
| lung congestion | during the period starting from admission till one day after delivery | the presence of lung congestion manifested by audible crepitations by chest auscultation |
| The need of diuretics | during the period starting from admission till one day after delivery | The presence of lung congestion manifested by respiratory distress (dyspnea, tachypnea, and decreased oxygen saturation below 90%) needing intravenous diuretics |
| arterial blood pressure | after 30 minutes from patient admission to the obstetric casuality | arterial blood pressure measured in mmHg |
| heart rate | after 30 minutes from patient admission to the obstetric casuality | the number of heart beats per minute |
| serum albumin | after 30 minutes from patient admission to the obstetric casuality | the level of albumin in blood (measured by g/ liter |
Countries
Egypt
Outcome results
None listed