Aging, Cognitive Function 1, Social
Conditions
Brief summary
The MoveMent project applies non-pharmacological strategies - physical exercise and cognitive training - that have been shown to be effective in promoting active and healthy aging. The objective is to study the molecular and neural mechanisms of these strategies to stimulate brain plasticity and improve brain health and cognitive functioning.
Detailed description
It is a randomized controlled study with three intervention groups - physical, cognitive and combined - and a control group. The intervention is carried out over 3 months, with a frequency of 5 weekly sessions of 45 minutes each. Cognitive training is applied through a computerized program, physical training consists of a walking aerobic program, and combined training arises from the addition of the two previous ones. 140 participants will undergo an exhaustive pre- and post-intervention evaluation that includes neuropsychological, neuroimaging, genetic and biochemical analysis before and after the intervention as well as physical and health status assessment. The present project aims to examine the independent and combined effects of exercise and cognitive stimulation in functional and structural brain plasticity, cognitive performance, emotional state and quality of life, and will determine the demographic and clinical factors that can modulate neuroplasticity. It will allow us to study the neurophysiological mechanisms by which the different types of intervention have an effect on the structure and functioning of the brain and cognition within an omics framework.
Interventions
BEHAVIORALPhysical exercise
The structured physical activity plan consists of a walking program with an initial progressive phase (first week: 30 minutes/session and second week: 45 minutes/session, with a Borg scale of perceived exertion between 9 and 10) and an improvement and maintenance phase (10 weeks, 45 minutes/session with a Borg scale of perceived exertion between 11 and 14).
BEHAVIORALCognitive training
We use a computerized cognitive training tele-medicine tool, designed by the Guttmann Institute: Guttmann Neuro Personal Trainer (PREVIRNET). Sessions will consist in activities of attention, memory and executive functions, also put in place progressively and parallel to the physical activity.
BEHAVIORALCombined training
Subjects included in this group receive both types of intervention.
Sponsors
Ministerio de Economía y Competitividad, Spain
Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Universitat Politècnica de Catalunya
Institut Guttmann
Germans Trias i Pujol Hospital
University of Pittsburgh
University of Barcelona
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Age between 50 and 70 * Underactive or sedentary (\<2 hours a week of physical activity). * Adequate visual, auditory and fine motor skills. * Able to speak and understand Catalan or Spanish language. * Accept to take part in the study and sign the informed consent according to the Declaration of Helsinki.
Exclusion criteria
* Mini mental State examination \< 24 and Montreal Cognitive Assessment- Short (MoCA -S) \< 6. * Diagnosis of mild cognitive impairment, dementia or other serious neurological, psychiatric, or systemic illness. * Presence of another illness that render them unable to engage in physical activity (signs or symptoms of chronic heart disease, chronic obstructive pulmonary disease, orthopedic problems). * History of drug abuse or alcoholism. * Psychotropic consumption * Contraindication to magnetic resonance imaging
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in functional and structural brain plasticity assessed with Magnetic Resonance Imaging | Baseline and 3 months | Resting state connectivity, structural connectivity, white matter integrity, tractography, volume of white and grey matter structures. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in metabolites and gene expression patterns | Baseline and 3 months | Metabolomic and transcriptomic analyses |
| Changes in cognitive function | Baseline and 3 months | Tests of executive function, attention, memory, language, visuospatial abilities and speed |
| Changes in emotional and functional status: Cognitive decline | Baseline and 3 months | Short Form of the Informant Questionnaire on Cognitive Decline in the Elderly (Short IQCODE) |
| Changes in emotional and functional status: Depression | Baseline and 3 months | Geriatric Depression Scale (GDS) |
| Changes in emotional and functional status: Mood | Baseline and 3 months | Adapted Visual Analog Mood Scale (VAMS) |
| Changes in health, fitness and physical activity: Cardiovascular risk factors | Baseline and 3 months | Cardiovascular risk factors |
| Changes in health, fitness and physical activity: Sleep | Baseline and 3 months | Pittsburgh Sleep quality Index |
| Changes in health, fitness and physical activity: Physical activity questionnaire | Baseline and 3 months | Spanish version of the reduced Minnesota leisure time physical and activity questionnaire (VREM) |
| Changes in health, fitness and physical activity: Fitness | Baseline and 3 months | One-mile Rockport walk test |
| Changes in health, fitness and physical activity: Physical activity monitoring | Baseline and 3 months | Polar Loop activity monitoring device. |
| Changes in emotional and functional status: Clinical outcome | Baseline and 3 months | Spanish version of the Clinical Outcomes in Routine Evaluation - Outcome Measure (CORE-OM) |
Other
| Measure | Time frame | Description |
|---|---|---|
| Changes in global cognitive function | Baseline and 3 months | Mini mental state examination |
Countries
Spain
Outcome results
None listed