Growth Disorders, Short Stature
Conditions
Keywords
Bone age,, Height prediction, Growth
Brief summary
Bone age assessment in children is based on the interpretation of hand x-ray scans according to Greulich and Pyle (GP) standard atlas and frequently used for evaluating growth and puberty in children and adolescents. To address the disadvantage of repeated irradiation, the need for specialized radiation centers, heavy equipment and subjective reading a new device, SonicBone was developed. SonicBone utilizes a quantitative ultrasonographic technology of ultrasonic (US) waves, propagating along a measured bone distance. The aim of the study is to evaluate an ultrasound based device, SonicBone, compared to the current method in children. The investigators will be compared the US assessment to available bone age X-ray that exists in the medical files of the patients. The investigators will not do bone age X-ray scans especially for the current study.
Detailed description
Bone age assessment in children is based on the interpretation of hand x-ray scans according to Greulich and Pyle standard atlas and frequently used for evaluating growth and puberty in children and adolescents. To address the disadvantage of repeated irradiation, the need for specialized radiation centers, heavy equipment and subjective reading a new device, SonicBone was developed. SonicBone utilizes a quantitative ultrasonographic technology of ultrasonic (US) waves, propagating along a measured bone distance. The aim of the study is to evaluate the ultrasound based device, SonicBone, and to compare it to the current method used in children. The SonicBone device (Rishon Lezion, Israel) is a small (50cm X 25cm X 25cm), portable, bone sonometer, which measures two parameters: 1. speed of propagation through bone (speed-of-sound, SOS, m/sec) of inaudible high frequency waves of a short ultrasound pulse; and 2. attenuation (ATN; the decay rate) of the sound wave by the bone as a function of the distance it travels between a transmitter probe and a receiver probe15. The hand is measured by: 1- wrist (W), measuring SOS and ATN at the distal radius and ulna secondary ossification centers of the epiphyses; 2-metacarpals (MC), measuring SOS and ATN at the distal metacarpal epiphyses; and 3- phalange (P), measuring SOS and ATN along the bent proximal third phalanx shaft, growth plate and epiphysis. The average of those 3 readings is define as the child's bone age by SonicBone. All ultrasonic examinations will be conducted at the Pediatric Endocrinology Clinic, by a trained technician. X-ray scans will be evaluated independently by a pediatric endocrinologist according to the GP atlas.
Interventions
DEVICESonicBone Ultrasound
Bone age assessment by SonicBone Ultrasound. The patient needs to put his/her wrist in 3 positions.
DEVICEWrist X-ray
Bone age assessment by Wrist X-ray
Sponsors
Meir Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
42 Months to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* Children 3.5-18 years old refered to the endocrine pediatric clinic due to short stature or other growth abnormalities
Exclusion criteria
* Children with bone disease * Children who within the last year took medications which might change bone metabolism or mineralization
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| bone age | through study completion, an average of 1 year | Bone age in years |
Countries
Israel
Contacts
Primary ContactAlon Eliakim, Prof.
Backup ContactDan Nemet, Prof.
Outcome results
None listed