Effect of Intravenous Dexamethasone Before Spinal Anesthesia on Post-cesarean Section Pain

Effect of Intravenous Dexamethasone Before Spinal Anesthesia on Post-cesarean Section Pain: Randomized Controlled Trial

Status

UNKNOWN

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03122756

Enrollment

100

Registered

2017-04-21

Start date

2017-08-01

Completion date

2018-10-31

Last updated

2018-08-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cesarean Section

Keywords

Intravenous Dexamethasone, Spinal Anesthesia, Post-cesarean Section Pain

Brief summary

\*Aim of the Work This study aims to assess the efficacy of intravenous injection of dexamethasone prior to spinal anesthesia in reducing post-cesarean section pain in women undergoing cesarean section.

Detailed description

\*Research Hypothesis: In women undergoing cesarean section, intravenous injection of dexamethasone prior to spinal anesthesia may reduce post-cesarean section pain. \*Research Question: In women undergoing cesarean section, does injecting intravenous dexamethasone prior to spinal anesthesia reduce post-cesarean section pain?

Interventions

DRUGDexamethasone

Intravenous injection of dexamethasone 0.1 mg/kg maximum 8 mg (diluted with distilled water to 2 mL) just prior to administration of spinal anesthesia.

OTHERNormal Saline

Intravenous injection 2 mL intravenous normal saline (0.9 %) just prior to administration of spinal anesthesia.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Inclusion Criteria: * A gestational age of 38 weeks or more and planned for elective cesarean section. * Living fetus. * Any number of previous cesarean section. * Intact amniotic membranes. * No history of bleeding tendency. *

Exclusion criteria

* Refuse to participate after counseling. * Contraindication to spinal anesthesia (coagulopathy significant hypovolemia systemic or local sepsis - increased intracranial pressure - local anesthetic or fentanyl allergy). * High risk pregnancies as pre-eclampsia, any medical disorder (diabetes mellitus, cardiac disease or and thyroid disease). * Contraindication to corticosteroids e.g. systemic fungal infection * Steroid medication one week before the operation. * Chronic pain or daily intake of analgesic. * Abnormal placentation e.g. placenta previa. * Intrauterine infection.

Design outcomes

Primary

Measure	Time frame	Description
change in post-cesarean pain	2, 4, 8 and 12 hours after the procedure	post-cesarean pain degree scored by the patient on Visual Analogue Scale

Secondary

Measure	Time frame	Description
sensory recovery	2, 4, 8 and 12 hours after the procedure	sensory recovery time by cold object
motor recovery	2, 4, 8 and 12 hours after the procedure	motor recovery time on Bromage scale
nausea	2, 4, 8 and 12 hours after the procedure	postoperative nausea
vomiting	2, 4, 8 and 12 hours after the procedure	postoperative vomiting
shivering	2, 4, 8 and 12 hours after the procedure	postoperative shivering

Countries

Egypt

Contacts

Primary ContactMahmoud AA ElShourbagy, MD

elshourbagym22@hotmail.com+201001448189

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026