Healthy
Conditions
Keywords
oxytocin, social cognition, fMRI, empathy
Brief summary
The aim of the present experiment is to examine oxytocin's behavioral and neural effects on social pain empathy
Detailed description
In the current study, the investigators plan to examine whether oxytocin modulates behavior and neural activity during observing another person being excluded in an online ball-tossing game (a modified cyberball paradigm).
Interventions
intranasal administration of oxytocin
DRUGplacebo treatment
intranasal administration of placebo
Sponsors
University of Electronic Science and Technology of China
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy participants without past or current psychiatric or neurological disorders
Exclusion criteria
* history of head injury * medical or psychiatric illness * smoking or drinking 24 hours before experiment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neural activity changes associated with oxytocin administration | 45-60 minutes after drug administration | fMRI-assessed brain activity during observing other being socially excluded |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Behavioral changes associated with oxytocin administration: ball-tossing | 45-60 minutes after drug administration | Number of tosses to the other players (the excluder, new player, or previously excluded player) |
Countries
China
Contacts
Primary ContactKeith Kendrick, Dr.
Outcome results
None listed