Obesity, Overweight
Conditions
Keywords
weight loss, Almond, Pistachio, hypoenergetic diet, Nut
Brief summary
The purpose of the current study is comparing the effect of almond and pistachio, as the two common types of nuts, consumption on healthy obese and overweight female who following a hypocaloric diet for 12 weeks. The secondary aim of the current study is to evaluate of these two type of nuts on other cardiometabolic risk factors.
Interventions
BEHAVIORALAlmond Group
Obese or overweight female adults will be randomly allocated to have almond as afternoon snacks, while they have a hypoenergetic diet.
BEHAVIORALPistachio Group
Obese or overweight female adults will be randomly allocated to have Pistachio as afternoon snacks, while they have a hypoenergetic diet.
BEHAVIORALNut free group
Obese or overweight female adults will be asked to avoid nuts, seeds and nut products, while they have a hypoenergetic diet.
Sponsors
University of Nottingham
Tehran University of Medical Sciences
Novindiet Clinic
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Must be female * Must be 18-45 years of age. * Must have Body mass index (BMI) between 27-35 kg/ m². * Must be able to have moderate exercise. * Must be interested to have weight loss.
Exclusion criteria
* Have allergy to nuts * Participating in a research project involving weight loss or physical activity in the previous six months. * Pregnancy or lactation during the previous 6 months, or planned pregnancy in the next six months. * Taking medication that could affect metabolism or change body weight. * Report heart problems, chest pain, and cancer within the last five years. * Smoking * Menopause * Diagnosis of any chronic disease such as fatty liver, cancer, chemo/radio therapy, heart disease, immune compromised conditions, abnormal thyroid hormone level.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Weight | 12 Weeks | Body weight was taken to the nearest 0.1 kg using a digital calibrated scale (Omron Health Care, Hoofddorp, Netherland), whilst subjects wore light clothing and no shoes. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| fasting blood glucose | 12 Weeks | Fasting plasma glucose (FPG) were measured using the enzymatic colorimetric method. |
| HbA1c | 12 Weeks | Glycated hamoglobin (HbA1c) was measured by a colorimetric method after an initial separation by ion exchange chromatography (Biosystem, Barcelona, Spain). |
| HOMA-IR | 12 Weeks | Insulin resistance was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR), which was calculated by using the following formula HOMA-IR = \[fasting insulin (mU/l) × FPG (mmol/l)\]/22.5 |
| Waist circumference | 12 Weeks | Waist circumference (WC) was measured with a rigid measuring tape and recorded to the nearest 0.5 cm. WC was measured at the smallest horizontal circumference between the ribs and iliac crest (the natural waist), or, in case of an indeterminable waist narrowing, halfway between the lower rib and the iliac crest. |
| liver function tests | 12 Weeks | AST ALT |
| Insulin | 12 Weeks | Insulin was measured by using a radioimmunoassay with 125I-labeled human insulin and a human insulin antiserum in an immunoradiometric assay (IRMA) (Biosource, Dorest, Belgium) with a gamma-counter system (Gamma I; Genesys). |
| lipid profiles | 12 Weeks | Biochemical analysis of the serum total cholesterol (TC), triglyceride (TG), and high-density lipoprotein (HDL) cholesterol was carried out on a Selectra E auto analyzer (Vita Laboratory, Netherlands) following standard procedures of the Pars Azmoon diagnostic kits (Iran). The LDL cholesterol was calculated using the Friedewald formula. LDL cholesterol = TC - HDL cholesterol + (TG ÷ 2.2) |
Countries
Iran
Outcome results
None listed