Chronic Kidney Disease
Conditions
Brief summary
The investigators aim to evaluate the feasibility of a resistance exercise training program among individuals with CKD and its impact on endothelial and vascular function.
Detailed description
Resistance exercise training has been shown to improve cardiovascular health including endothelial function in general populations, but studies in patients with chronic kidney disease (CKD) are limited. The investigators aim to evaluate the feasibility and acceptability of a resistance exercise training program among individuals with CKD and its impact on endothelial and vascular function as measured by brachial artery flow-mediated dilation, pulse-wave velocity and carotid artery stiffness. To accomplish this goal the investigators propose to conduct a 12-week pilot randomized controlled trial of twice a week resistance exercise training among 32 adults with CKD. The results of this study will inform the design and implementation of a larger trial evaluating the impact of resistance exercise training on adverse outcomes in patients with CKD including CKD progression.
Interventions
BEHAVIORALResistance exercise training
12-week resistance exercise training program, 2 times per week, 45 min per session. Eight exercises will be used to include large upper and lower body muscle groups (leg press, leg extension, leg curl, chest press, shoulder extension, biceps curl, abdominal crunch and back extension). The baseline one repetition maximum will be used to set initial training loads.
Sponsors
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
University of Illinois at Chicago
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* CKD stage 3 or 4 (eGFR 15-60 ml/min/1.73m2)
Exclusion criteria
* Currently institutionalized * Kidney transplant or dialysis * NY Heart Association class 3-4 heart failure * Dementia or cognitive impairment * Unstable angina or coronary revascularization within the last 3 months * Uncontrolled arrhythmia * Severe chronic lung disease * Orthopedic, neurologic or other condition that would preclude resistance exercise training * Pregnancy * Uncontrolled hypertension (systolic \> 160 mmHg and diastolic \>90 mmHg)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Endothelial function | 3 months | Measured by brachial artery flow-mediated dilation (FMD) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Carotid artery stiffness | 3 months | Measured by non-invasive ultrasound |
| Self-reported physical activity | 3 months | Assessed by the MESA (Multiethnic Study of Atherosclerosis) Typical Week Physical Activity Survey |
| Objectively measured physical activity | 3 months | Assessed by a physical activity monitor (ActiGraph GT3X+) |
| Vascular function | 3 months | Measured by pulse wave velocity |
| Serum LDL-cholesterol | 3 months | Measured using standard procedures |
| Serum HDL-cholesterol | 3 months | Measured using standard procedures |
| Muscle strength | 3 months | Assessed by the amount of weight lifted in a single chest press and leg press (1 RM). |
| Systolic blood pressure | 3 months | Measured using standard procedures |
Countries
United States
Outcome results
None listed