NAFLD
Conditions
Keywords
Reduction of liver fat
Brief summary
The impact of popular diets on liver-related health is unclear. In this randomized, controlled trial, patients with NAFLD will be randomized to one of two popular diets or a placebo diet.
Detailed description
Subjects will include patients with MRI-verified NAFLD, with no concurrent liver diseases. Randomization will be done to either a control diet, the 5:2 diet or a low-carb-high-fat diet. The subjects will follow the diet for three months, after which a new MRI is performed. Main outcomes measure is reduction in liver fat.
Interventions
BEHAVIORAL5:2 diet
Dietary intervention according to 5:2 diet during three months.
BEHAVIORALLCHF
Dietary intervention according to LCHF diet during three months.
BEHAVIORALPlacebo diet
Placebo diet: normal dietary advice
Sponsors
Karolinska University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Known NAFLD
Exclusion criteria
* Other forms of liver disease * Bolus insulin treatment * Cirrhosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Liver fat | Three months | MRI-measured liver fat content |
Countries
Sweden
Outcome results
None listed