Mammaplasty, Microsurgery, Free Tissue Flaps
Conditions
Keywords
deep inferior epigastric perforator flap, fluid restriction, catecholamine restriction
Brief summary
By comparison of two different protocols with diverse fluid/ catecholamine administration limits (fluid restriction vs. catecholamine restriction with target systolic blood pressure \> 100 mmHg) the investigators would like to reveal the impact of intraoperative blood pressure management on the survival rate of free deep inferior epigastric artery flaps for breast reconstruction.
Interventions
crystalloid restrictive anesthesia protocol
DRUGCatecholamines
catecholamine restrictive anesthesia protocol
Sponsors
University of Regensburg
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Informed consent for study participation * Every patient undergoing breast reconstruction (primary and secondary reconstruction) with deep inferior epigastric perforator flap at our hospital is offered to participate in the study
Exclusion criteria
* No informed consent for study participation * Patients with a high thromboembolic risk profile * During pregnancy and breastfeeding * Minors * Patients with a health care proxy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Free flap survival rate | 5 days postoperatively | Rates of (partial) flap loss in each study arm |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Period of hospitalization | up to 14 days | Length of postoperative hospitalization in each study arm |
Countries
Germany
Contacts
Primary ContactAlexandra Anker, MD
Outcome results
None listed