Healthy
Conditions
Brief summary
The main aim of this project is to explore the neuro-anatomical and -physiological correlates of meditation on attention and emotion-regulation. By investigating this, our scientific goal is to more generally identify the mechanisms and biomarkers of health and mental well-being. Therefore, the investigators use non-invasive imaging like Magneto-EncephaloGraphy (MEG), ElectroEncephaloGraphy (EEG), functional and anatomic Magnetic Resonance Imaging (MRI; including Diffusion tensor - DTI). These brain measures will then be linked to behavioral measurements. Experimental methods (i.e., simple computer tasks) will be used to measure attention, conscious perception and regulation of pain and emotion.
Interventions
OTHERMagneto-encephalography (MEG)
Magneto-encephalography
OTHERElectro-encephalography (EEG)
Electro-encephalography
OTHERFunctional Magnetic Resonance Imaging (fMRI)
Functional Magnetic Resonance Imaging
OTHERAnatomical Magnetic Resonance Imaging (aMRI)
Anatomical Magnetic Resonance Imaging
OTHERMeditation
Meditation
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
25 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Age : 25-70 * Being affiliated to a social security system. * Motivated to participate in this study.
Exclusion criteria
* Medication acting on the central nervous system * Opioids, Antidepressive Agents. * Actual or previous neurological or psychiatric illnesses * Chronic pain or any other medical condition which is related to pain or an increased sensitivity to pain. * Not having a personal or family history of epilepsy * Alcohol or drugs consumption 2 days before or during the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Anatomical MRI scan | Day 1 | Brain structure |
| Functional MRI scan | Day1 | Brain activation: Haemodynamic response - BOLD signal. |
| EEG | Day 1 | Event-related potential fields : amplitude in fT and latency in ms. Oscillations : power spectral density and time-frequency oscillations in fT\^2/Hz |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Subjective experience of the participant | Day 1 | — |
| Studies biomarkers of inflammation | Day 1 | area of the inflamed site in mm\^2, obtained by automatic image processing of a photography |
| Behavioral measure : Speed of the performed task actions | Day 1 | Participants will perform behavioral computer tasks in which accuracy and speed is important. Performance behavior will be measured in this task: Speed of the performed task actions: in ms. |
| Psychophysiology : Heart | Day 1 | Heart Rate: pulses/minute |
| Behavioral measure : Accuracy of the performed task actions | Day 1 | Participants will perform behavioral computer tasks in which accuracy and speed is important. Performance behavior will be measured in this task: Accuracy of the performed task actions: number of errors and hits |
| Psychophysiology : Muscles | Day 1 | Electromyography (EMG): Recording the electrical activity produced by muscles; measured in mV. |
| Psychophysiology : Eyes | Day 1 | Eye gaze position: relative to center of the screen, in imm |
| Psychophysiology : Pupillar response | Day 1 | Pupillar response: pupil diameter, in mm. |
| Electrogastrogram | Day 1 | Recording the electrical signals that travel through the stomach muscles and control the muscles' contractions (waves/minute) |
| Psychophysiology : Heart rate variability | Day 1 | Heart rate variability (HRV): Using an electrocardiogram, the variation in the beat-to-beat interval; measured in ms. |
| Psychophysics: Pain threshold | Day 1 | Pain threshold: The threshold of pain or pain threshold is the point along a curve of increasing perception of a stimulus at which pain begins to be felt. The temperature in degrees Celcius at which heat becomes painful for a recipient. |
| Psychophysiology : Respiration | Day 1 | Respiration rate: breaths/minute |
Countries
France
Outcome results
None listed