Profound Hearing Impairment
Conditions
Keywords
Cochlear implantation, Deafness, Auditory cortex, Auditory plasticity, Tinnitus
Brief summary
Our main objective is to study how the extent of reorganization of the central auditory system is related to the binaural integration in cochlear implanted subjects with asymmetric hearing loss. Subjects with asymmetric hearing loss treated with a cochlear implant and a control group of normal hearing subjects will perform two tests for binaural integration (speech recognition in noise and spatial localization) and two tasks of non-linguistic sounds perception.
Detailed description
Cochlear implantation is the most efficient method to restore hearing in deaf patients. However, about 2/3 of patients have some residual hearing and these patients usually combine two types of auditory information (electrical and acoustical). It is important to know how the brain is processing during two distinct stimulations and how it is related to the auditory level of performance. Patients and controls will undergo a positron emission tomography scan brain imaging session during a simplified voice/non-voice discrimination task. For each tasks and brain imaging sessions, patients will be stimulated either with the non-implanted ear (acoustical stimulation), the cochlear implant (electrical stimulation) and using both modalities in a binaural condition.
Interventions
* Binaural hearing assessments: speech recognition in noise and sound source localization * Voice perception assessment: voice/non-voice discrimination task, free categorization task * Positron emission tomography examinations under ecological auditory stimuli (voice/non-voice discrimination task)
Sponsors
University Hospital, Toulouse
Centre de recherche Cerveau et Cognition (CERCO)
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Subjects with asymmetric hearing loss treated with a cochlear implant and a control group of normal hearing subjects
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* cochlear implantation\>3 months * signature of informed consent * affiliation to social service.
Exclusion criteria
* associated neurological disorder * protected subjects * epilepsy episodes * psychotropic medication * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differences in auditory brain activation between cochlear implanted asymmetric hearing loss subjects and normal hearing subjects in the binaural condition. | Day 1 | Prior to the imaging session, patients performed two human voice interpretation tests. link between temporal activations and performances obtained in binaural integration tasks in the patient group. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| differences in auditory brain activation. | Week 3 - Week 5 | Auditory brain activation when the better ear is acoustically stimulated in asymmetric hearing loss subjects and when one ear is stimulated in normal hearing subjects. |
| Performance level and the pattern of brain activation. | Week 3 - Week 5 | Acoustical or electrical stimulation in asymmetric hearing loss cochlear implanted subjects. |
| the asymmetry in auditory brain activation for asymmetric hearing loss cochlear implanted subjects. | Week 3 - Week 5 | Electrical and acoustical stimulation will be used. |
| link between binaural hearing performances and auditory brain activation in the binaural condition. | Week 3 - Week 5 | For the group of cochlear implanted subjects with asymmetric hearing loss. |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORMathieu Marx, Pr
University Hospital, Toulouse
Outcome results
None listed