Coronary Artery Disease, Fractional Flow Reserve, Magnetic Resonance Angiography
Conditions
Brief summary
This study aims to evaluate whether quantitative analysis of coronary MR angiogram would improve the detection of functionally-significant coronary artery stenosis.
Detailed description
Coronary MR angiography is performed with a 3.0-T imager with 32-channel coils. Qunatitative analysis of coronary MR angiogram is evaluated on the basis of the signal intensity (SI) profile along the vessel. Quantitative analysis of coronary MR angiogram (QCMRA) is calculated as \[1 - (SImin/SIref)\] x 100, where SImin is minimal SI and SIref is corresponding reference SI. Diagnostic performance of quantitative analysis of coronary MR angiogram for predicting functional significant coronary stenosis was evaluated by using fractional flow reserve (FFR) as the reference standard.
Interventions
DIAGNOSTIC_TESTCoronary MR angiography
Quantitative analysis of coronary MR angiogram
Sponsors
Seoul National University Bundang Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 years * 1 or more coronary stenoses in the major coronary artery with a vessel diameter ≥ 2mm on coronary MR angiogram * Patient who were planned to undergo invasive coronary angiography and fractional flow reserve
Exclusion criteria
* clinically unstable patient * a history of coronary revascularization * infiltrative cardiomyopathy, hypertropic cardiomyopathy, myocarditis * contraindication to use of adenosine * complete occlusion of target lesion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Presence of functionally significant coronary stenosis | within 1 month | fractional flow reserve \< 0.8 |
Countries
South Korea
Contacts
Primary ContactYeonyee E Yoon, MD
Outcome results
None listed