CLA and Vitamin D on Protein Turnover

Randomized Controlled Trial to Evaluate the Independent and Combined Effects of Conjugated Linoleic Acids and Vitamin D on Muscle Protein Turnover in Older Adults

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03115775

Acronym

Enrollment

Registered

2017-04-14

Start date

2017-05-12

Completion date

2019-08-31

Last updated

2019-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Protein

Brief summary

To conduct a randomized, double-blind, controlled clinical trial to determine the independent and combined effects of dietary conjugated linoleic acid (CLA) and vitamin D supplementation on anabolic signaling, the expression of growth regulatory factors, and muscle protein turnover in older adults.

Interventions

DIETARY_SUPPLEMENTConjugated linoleic acid

Intervention will last up to 8 weeks. Subjects will receive conjugated linoleic acid (4000 mg Tonalin FFA 80) daily.

DIETARY_SUPPLEMENTVitamin D

Intervention will last up to 8 weeks. Subjects will receive vitamin D3 (2000 IU) daily.

DIETARY_SUPPLEMENTConjugated linoleic acid and Vitamin D

Intervention will last up to 8 weeks. Subjects will receive conjugated linoleic acid (4000 mg Tonalin FFA 80) and vitamin D3 (2000 IU) daily.

OTHERCorn oil (placebo)

Intervention will last up to 8 weeks. Subjects will receive corn oil (4000 mg) daily.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Intervention model description

Randomized, double-blind, controlled clinical trial

Eligibility

Sex/Gender

ALL

Age

65 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

* BMI \>/= 18.5 and \</= 35.0 * Serum 25OH-VitD3 \< 35 ng/ml

Exclusion criteria

* Diabetes * COPD

Design outcomes

Primary

Measure	Time frame	Description
Change in post-absorptive muscle protein synthesis	Baseline and 8 weeks	A stable isotope labelled amino acid infusion, in conjunction with blood and muscle tissue sampling and mathematical modelling analysis will be used to measure post-absorptive muscle protein synthesis.
Change in combined amino acid and insulin stimulated muscle protein synthesis	Baseline and 8 weeks	A stable isotope labelled amino acid infusion, in conjunction with insulin and mixed amino acid infusion, blood and muscle tissue sampling and mathematical modelling analysis will be used to measure muscle protein synthesis.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 25, 2026