Cerebral Infarction
Conditions
Brief summary
This is a biomedical, single-center, and prospective study of a consecutive patients cohort in acute ischemic stroke with carotid plaque.
Detailed description
The main objective of this study is to evaluate the prevalence of the contrast taking carotid plaques in these acute ischemic strokes. The secondary objectives are: * to determine the clinical, sonographic, CT scanner and MRI characteristics of patients in constituted acute cerebral ischemia with carotid atherosclerotic plaque taking contrast to the doppler ultrasound. * to explore of the plaque contrast enhancement at 6 months (new injection).
Interventions
OTHERContrast injection Sonovue®
In addition to standardized assessment routine care, a contrast injection will be performed during the neck vessels doppler ultrasound.
Sponsors
Jennifer YEUNG (neurologist)
Aurélien MAURIZOT (angiologist)
Simon CHABAY (angiologist)
Daniela STANCIU (neurologist)
Versailles Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients aged at least 18 years hospitalized with ischemic stroke signs in the carotid territory, objectified on brain MRI with positive DWI. * Carotid plaque \> 2.5 mm thickness in the ipsilateral carotid territory to the AIC, low echogenicity (Type 1, 2, 3, and 4a of the classification Geroulakos) measured by the assessment GSM (median gray level). * Free and informed consent patient or his representative for contrast injection microbubble. * Affiliated to health insurance.
Exclusion criteria
* Severe cerebral infarction with NIHSS\> 25 * No-indications to the contrast medium injection * Recent myocardial infarction, unstable angina. * Heart failure stage III / IV New York Heart Association. * Cardiac shunt left-right, respiratory distress. * Allergy to albumin or contrast agents. * Carotid plaques and hyperechoic calcified (however these plaques will be counted to determine their prevalence in acute AIC). * Carotid dissection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Contrast enhancement of carotid plaque prevalence in ultrasound doppler | Day 1 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Patient's demographics data | Day 1 | — |
| Patient's sonographic and MRI characteristics. | Day1 | confirmation of the recent character of stroke on the DWI, search for stroke sequelae and white matter disease on the FLAIR, search of the thrombus on the T2\*, search occluded artery on the 3DTOF |
| describe the aspect of the carotid plaque on CT angiography. | between 1 to 5 days | NASCET stenosis and the aspect (smooth, irregular, ulcerated) |
| Persistence , decrease or loss of contrast enhancement in ultrasound doppler. | Month 6 | — |
| Cerebral infarction recurrence | Month 6 | — |
Countries
France
Outcome results
None listed