Comparison of Plasmalyte A, Normal Saline and Ringer Lactate as Intraoperative Fluid During Renal Transplantation

Comparison of Plasmalyte A, Normal Saline and Ringer Lactate as Intraoperative Fluids in Patients Undergoing Renal Transplantation.

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03115060

Enrollment

105

Registered

2017-04-14

Start date

2015-04-01

Completion date

2018-04-30

Last updated

2017-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acid-Base Balance Disorder

Brief summary

Fluid management being an important component of surgery becomes more challenging for an anesthesiologist in case of renal transplant. Ischemia-reperfusion injury is an inevitable consequence of kidney transplantation, leading to metabolic acidosis .Normal saline (NS; 0.9% NaCl) is administered during kidney transplantation to avoid the risk of hyperkalemia associated with potassium-containing fluids. Plasmalyte is another fluid which can be used and probably will lead to better metabolic profile in these group of patients.The primary objective of this study will be to compare the effects of using normal saline (NS), Ringer lactate and Plasmalyte as intravenous fluids on acid-base balance and electrolytes during living donor kidney transplantation. Secondary outcomes assessed will be the effect on renal function.

Interventions

DRUGintravenous fluid administration WITH NORMAL SALINE, PLASMALYTE A, OR RINGER LACTATE

intravenous fluid to be used for maintainance and replacement during renal transplant surgery will be normal saline, ringer lactate or plasmalyte A depending on the arm of intervention

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Inclusion criteria

* patients undergoing elective living donor renal transplant

Exclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
acid base balance, 4 readings intraoperaively to be taken using arterial blood sample of the patient	during the surgery	pH, pCO2, pO2, HCO3,Base deficit, Na, K are the values normally measured in acid base analysis

Secondary

Measure	Time frame	Description
serum creatinine on day 1, 2 and 7 of surgery	day 1, 2 and 7	This is a function of kidney measure and will tell about the success of Renal Transplant
intraoperative hemodynamics in all patients	intraoperatively	—

Countries

India

Contacts

Primary ContactTanvir samra, MD Anaesthesia

drtanvirsamra@yahoo.co.in7087008799

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026