Food Preferences, Obesity
Conditions
Brief summary
Study into the endocannabinoid response to consuming a palatable versus a neutral food.
Interventions
OTHERFood palatability
Food palatability is modulated
Sponsors
Wageningen University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy (self-report) * Dutch * Evaluating one of the used foods as palatable * Evaluating one of the used foods as neutral * Hb value between 8.1 and 11.0 mmol/L at screening
Exclusion criteria
* restraint eating * lack of appetite * difficulties eating/swallowing * endocrine disorders * energy restricted diet two months prior to study * weight change \> 5 kg in two months prior to study * stomach or bowel disease * taste or smell disorders (self-report) * not consuming foods used in the study * smoking \> 1 cigarette per day * drinking \> 21 units alcohol per week
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Endocannainoid levels | prior to, during and two hours after eating | To assess changes in endocannabinoid plasma levels prior to, during and after eating a palatable versus a neutral food |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pancreatic polypeptide (pg/ml) | prior to, during and two hours after eating | To assess changes in pancreatic polypeptide plasma levels prior to, during and after eating a palatable versus a neutral food |
| Ghrelin (pg/ml) | prior to, during and two hours after eating | To assess changes in ghrelin plasma levels prior to, during and after eating a palatable versus a neutral food |
Outcome results
None listed