Sebum Collection and Skin Barrier Function Analysis

Sebum Collection for Analysis and Correlation to Sebum Production, Barrier Function, and With Cutaneous and Internal Inflammatory Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03112876

Acronym

Sebum

Enrollment

Registered

2017-04-13

Start date

2014-06-27

Completion date

2016-02-26

Last updated

2017-04-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne, Aging, Atopic Dermatitis, Smoking

Keywords

younger age, older age, atopic dermatitis, acne, smoker

Brief summary

The goal is this study is to evaluate how the skin surface lipid composition is correlated with overall sebum production, barrier function, and inflammatory disease status. We hypothesize that there will be differences in the skin surface composition among subjects of various groups: 1. Young vs older healthy population 2. Atopic dermatitis vs Acne vs Healthy controls 3. Active smokers vs non-smoker controls

Detailed description

This study will be conducted through the use of painless tapes to collect lipid. These will be applied to the skin and removed. Secondly, the barrier function will be evaluated through the use of non-invasive painless devices that measure sebum, skin water loss, and skin hydration.

Interventions

OTHERSkin Surface Lipid Collection and Skin Barrier Function

All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

12 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Subjects that are 12 years of age or older

Exclusion criteria

* None

Design outcomes

Primary

Measure	Time frame	Description
Lipid Profile-aging	1 day	The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.
Lipid Profile-acne	1 day	The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.
Lipid Profile-atopic dermatitis	1 day	The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.
Lipid Profile-smoking	1 day	The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.

Secondary

Measure	Time frame	Description
Skin Barrier Function- aging	1 day	The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.
Skin Barrier Function- acne	1 day	The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.
Skin Barrier Function- atopic dermatitis	1 day	The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.
Skin Barrier Function- smoking	1 day	The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026