Endometrial Neoplasms, Ovarian Neoplasms
Conditions
Brief summary
This study evaluates the usefulness of serum levels of trefoil factor 3 (TFF3), secreted frizzled related protein 4 (sFRP-4), reactive oxygen species modulator 1 (Romo1) and nuclear factor (NF)-κB as potential diagnostic and prognostic biomarkers in ovarian carcinoma.
Interventions
DIAGNOSTIC_TESTTFF3, SFRP4, Romo1, NFKB
Blood samples of all participants will be collected.
Sponsors
Istanbul University
Ilker Kahramanoglu
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Primary diagnosis of epithelial ovarian carcinoma.
Exclusion criteria
* Patients with recurrence. * Patients who received neoadjuvant chemotherapy or radiotherapy * Presence of any secondary malignancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Efficacy of serum levels of trefoil factor 3 (TFF3), secreted frizzled related protein 4 (sFRP-4), reactive oxygen species modulator 1 (Romo1) and nuclear factor (NF)-Κb in discrimination of benign and malignant gynecologic disease | 2 days | To measure serum levels of trefoil factor 3 (TFF3), secreted frizzled related protein 4 (sFRP-4), reactive oxygen species modulator 1 (Romo1) and nuclear factor (NF)-κB between groups and to identify a possible significant diagnostic marker |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Efficacy of serum levels of trefoil factor 3 (TFF3), secreted frizzled related protein 4 (sFRP-4), reactive oxygen species modulator 1 (Romo1) and nuclear factor (NF)-Κb in predicting overall survival and disease-free survival | 1 year | To determine any relationship between prognosis of ovarian cancer and serum levels of four different biomarkers |
Countries
Turkey (Türkiye)
Outcome results
None listed