Atrophic Rhinitis
Conditions
Keywords
atrophic rhinitis
Brief summary
The goal of the suggested research is to develop a treatment option using platelet rich plasma injection for regeneration of atropic nasal mucosa. Specific aims of the suggested research is to (1) access the effect of platelet rich plasma in the patients with atropic rhinitis . Moreover, we will (2) compare the conservative treatments including saline nasal irrigation or saline nasal spray.
Detailed description
Clinical trials of platelet rich plasma injection for regeneration of atropic nasal mucosa. * Injection interval and follow-up duration * Injection interval 2 weeks (upto total 3 consecutive injection) * Follow-up duration: 6 months * Observation items, clinical assessment items and evaluation method * Access the nasal mucosal status using nasal speculum. * Access the nasal mucociliary function using saccharin test (primary outcome; once per month). * Fill in the nasal symptom scores using Nasal Obstruction Symptom Evaluation(NOSE) Instrument, Sino-Nasal outcome Test 20, and Visual analog scale (secondary outcome; once per month) * The other atrophic rhinitis patients who did not want to perform platelet rich plasma injection * Random allocation to saline nasal irrigation or saline nasal spray group * Perform same observation items, clinical assessment items and evaluation method as well as platelet rich plasma injection group
Interventions
DEVICESaline nasal spray
two puffs of isotonic saline nasal spray twice daily
DEVICEPlasma rich platelet injection
Plasma rich platelet injection with 26-gauge needle and 2cc syringe on inferior turbinate mucosa
Sponsors
Seoul St. Mary's Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Platelet Rich Plasma Injection group : 12 patients anticipated Saline spray group : 12 patients anticipated
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults (\>18 years) * Complaint of atrophic rhinitis symptoms including nasal crusting, nasal burning sensation, and postnasal drip * Atrophic rhinitis view on nasal endoscopic finding * Patients who informed sufficient about other atrophic rhinitis treatment options including Young's operation, lubricants, or saline irrigation, but, want more other active treatment option.
Exclusion criteria
* Platelet related disorders * Low serum platelet (\<100,000/㎕) * Other hematologic disorders * Septicemia * Take anticoagulant drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The change of mucociliary clearance function using the saccharin test | 2, 4, 8, 12, and 24th week | The change in saccharin test time of the 2, 4, 8, 12, and 24th week after first treatment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The change of nasal symptoms using the Visual analog scale | 2, 4, 8, 12, and 24th week | The change in Visual analog scale scores of the 2, 4, 8, 12, and 24th week after first treatment |
| The change of nasal symptoms using the Nasal Obstruction Symptom Evaluation(NOSE) Instrument | 2, 4, 8, 12, and 24th week | The change in NOSE total scores of the 2, 4, 8, 12, and 24th week after first treatment |
| The change of nasal symptoms using the Sino-Nasal outcome Test 20 | 2, 4, 8, 12, and 24th week | The change in Sino-Nasal outcome Test 20 scores of the 2, 4, 8, 12, and 24th week after first treatment |
Countries
South Korea
Outcome results
None listed