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Antimicrobial Pastes and Clinical Cases of Apexogenesis

Clinical and Microbiological Evaluation of a Series of Clinical Cases of Permanent Teeth With Incomplete Apexogenesis and Traumatic Necrosis, Treated With Double Antimicrobial Paste, Revascularization Procedures, and MTA

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03112291
Enrollment
14
Registered
2017-04-13
Start date
2011-11-25
Completion date
2016-10-08
Last updated
2017-04-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Apexification, Dental Trauma, Root Canal Therapy

Keywords

anti-microbial agents, apexification, dental pulp, endodontics, root canal therapy, dental trauma

Brief summary

The aim of this study was to perform a clinical and microbiological evaluation of teeth with incomplete apexogenesis and traumatic necrosis that were treated with a revascularization technique, evaluating the microbial reduction after the use a double antibiotic paste. Furthermore, the investigation also aims to identify the presence of Enterococcus faecalis and Porphyromomas gingivalis within the root canal system.

Detailed description

This investigation is a longitudinal prospective interventional study of a series of cases. Patients who sought treatment at the Faculty of Dentistry from June 2011 to September 2015 were selected. They should have one permanent tooth with traumatic necrosis.

Interventions

PROCEDUREApexification

Apexification forms a calcified barrier in teeth with open apexes and pulp necrosis. It is used to treat immature teeth, but it does not promote the continuity of root formation.

Sponsors

Adriana Kelly de Sousa Santiago Barbosa
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Intervention model description

This investigation is a longitudinal prospective interventional study of a series of cases

Eligibility

Sex/Gender
ALL
Healthy volunteers
Yes

Inclusion criteria

* They should have one permanent tooth with traumatic necrosis, which in turns should show color alteration, fistulae, periapical lesion, and/or internal or external root resorption, pain, or absence of pulp response to sensitivity tests at a clinical examination to be considered necrotic. Male and female patients who had not undergone antibiotic therapy 3 months before the treatment were included and clinical and radiographic examinations confirmed pulp necrosis.

Exclusion criteria

* Patients who did use antibiotics * Patients who did loss of temporary coronary sealing between treatment sessions * Patients who give up the research

Design outcomes

Primary

MeasureTime frameDescription
Number of teeth with apex closed according to nolle stages.24 monthsThe apical closure of the teeth was evaluated by radiography /computed tomography every 3 months according to the nolla stages, in which a tooth is considered to be a closed apex in stage 9 of nolla

Secondary

MeasureTime frameDescription
Number of patients with clinically and radiographically observed fistulas6 monthsThe occurrence of fistulas through clinical signs and symptoms was observed for a period of 6 months in which it was recorded in medical records

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026