Obesity
Conditions
Brief summary
This study will determine whether changes in energy balance alter regional neuronal activation of brain regions associated with food intake in individuals screened to be either resistant or prone to obesity. Specifically, it will determine whether foods of hedonic value elicit changes in regional neuronal activity in the fasted and fed state in obese-resistant and obese-prone men and women in varying states of energy balance.
Interventions
OTHERUnderfeeding Feeding Period
OTHEREucaloric Feeding Period
OTHEROverfeeding Feeding Period
Sponsors
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
University of Colorado, Denver
Study design
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
25 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
In the obese-prone group: * BMI between 20-30 * Report at least one obese first-degree relative * Self-describe as struggling with weight * Weight-stable for at least 3 months prior to study participation In the obese-resistant group: * BMI between 17-25 * Report no obese first-degree relatives * Self-describe as naturally thin and have never been overweight * Overall weight stability
Exclusion criteria
* Significant medical or psychiatric disease * History of eating disorder * Left handed * Unable to complete an MRI scan (e.g., metal in body, claustrophobic)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in neuronal response to food vs. nonfood objects in fasted vs. fed states | Day 5 of each of the three 5-day study periods (Eucaloric, Overfeeding, Underfeeding) | Change in neuronal response to food vs. nonfood objects in the overfed and underfed feeding periods as compared to the eucaloric period between fasted and fed states in obese-prone as compared to obese-resistant individuals. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in food cravings | At baseline and both before and after a meal on Day 5 of each of the three 5-day study periods (Eucaloric, Overfeeding, Underfeeding). | Change in food cravings (questionnaire) before vs. after a meal in the overfeeding and underfeeding periods compared to the eucaloric feeding periods between obese-resistant and obese-prone individuals. |
| Change in leptin levels | At baseline, in the fasted state on Day 5 of each of the three 5-day study periods (Eucaloric, Overfeeding, Underfeeding) and at 30, 90, 120, 150 and 180 minutes after a meal on Day 5 of each of the three 5-day study periods. | Change in blood leptin levels before vs. after a meal in the overfeeding and underfeeding periods compared to the eucaloric feeding periods between obese-resistant and obese-prone individuals. |
| Change in ghrelin levels | At baseline, in the fasted state on Day 5 of each of the three 5-day study periods (Eucaloric, Overfeeding, Underfeeding) and at 30, 90, 120, 150 and 180 minutes after a meal on Day 5 of each of the three 5-day study periods. | Change in blood ghrelin levels before vs. after a meal in the overfeeding and underfeeding periods compared to the eucaloric feeding periods between obese-resistant and obese-prone individuals. |
| Change in appetite ratings | At baseline, in the fasted state on Day 5 of each of the three 5-day study periods (Eucaloric, Overfeeding, Underfeeding) and at 30, 90, 120, 150 and 180 minutes after a meal on Day 5 of each of the three 5-day study periods. | Change in appetite ratings via visual analog scale (VAS; 0-100) before vs. after a meal in the overfeeding and underfeeding periods compared to the eucaloric feeding periods between obese-resistant and obese-prone individuals. |
| Change in neuronal response to hedonic vs. basic food images | Day 5 of each of the three 5-day study periods (Eucaloric, Overfeeding, Underfeeding) | Change in neuronal response to hedonic vs. basic food images in the overfed and underfed feeding periods as compared to the eucaloric period between fasted and fed states in obese-prone as compared to obese-resistant individuals. |
| Change in body weight | Baseline and every 6 months for up to 5 years after study participation. | Change in body weight from baseline for up to 5 years in obese-resistant and obese-prone individuals |
| Change in PYY levels | At baseline, in the fasted state on Day 5 of each of the three 5-day study periods (Eucaloric, Overfeeding, Underfeeding) and at 30, 90, 120, 150 and 180 minutes after a meal on Day 5 of each of the three 5-day study periods. | Change in blood Peptide YY (PYY) levels before vs. after a meal in the overfeeding and underfeeding periods compared to the eucaloric feeding periods between obese-resistant and obese-prone individuals. |
Countries
United States
Outcome results
None listed