Renal Transplant Recipients
Conditions
Keywords
renal transplant recipients, exercise, heart rate variability, Cardiovascular mortality
Brief summary
Introduction: Renal transplantation represents the therapeutic mode with more durable treatment, greater cost-effectiveness, survival benefits and quality of life of the patients, however, with high cardiovascular mortality. Objectives: To evaluate the acute and chronic effects on heart rate variability and the impact of chronic kidney disease on cardiorespiratory fitness in renal transplant recipients following a full-body Vibration training program. Methods: It will be a blinded randomized clinical trial (patient, evaluator and statistician), controlled and endowed with secrecy of allocation, to be performed in the Cardiopulmonary Physiotherapy Laboratory of the Physiotherapy Department of the Federal University of Pernambuco. Renal transplant recipients will be recruited at the Nephrology outpatient clinic of the Hospital das Clínicas de Pernambuco, according to the following inclusion criteria: age between 18 and 59 years, who underwent transplantation at least one year before and present a stable transplant function through the level Of creatinine
Detailed description
It will be a blinded randomized clinical trial (patient, evaluator and statistician), controlled and endowed with secrecy of allocation, to be performed in the Cardiopulmonary Physiotherapy Laboratory of the Physiotherapy Department of the Federal University of Pernambuco. Renal transplant recipients will be recruited at the Nephrology outpatient clinic of the Hospital das Clínicas de Pernambuco, according to the inclusion criteria
Interventions
Training on the Vibrating platform will be performed with the patients in the static position.The exercises will be performed in the first two weeks for 10 minutes consisting of 60 seconds of low intensity and 30 seconds of standing rest in the anatomical position. From the second week to the end of the twelfth week (24 sessions) will be performed 15 minutes corresponding being 60 seconds of high intensity interspersed with 30 seconds of rest standing in the anatomical position. In the second month, the patient should be well adapted to the stimuli of the platform keeping the frequency of 35Hz and the amplitude 4mm. Monitoring of blood pressure, heart rate and peripheral oxygen saturation should be done every 5 minutes.
Sponsors
Universidade Federal de Pernambuco
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Intervention model description
Intervention group and control group
Eligibility
Sex/Gender
ALL
Age
18 Years to 59 Years
Healthy volunteers
No
Inclusion criteria
* Age between 18 and 59 years * who underwent transplantation at least one year before * present a stable transplantation function through the creatinine level \<1.8 mg / dL * No drug use with ability to modify the autonomic nervous system, such as sympatholytic drugs
Exclusion criteria
* unstable hypertension; * Amyloidosis; * Congestive heart failure, recent myocardial infarction, unstable angina; * Musculoskeletal abnormality that impairs the performance of the exercises; * Have a metal implant or cardiac pacemaker.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| heart rate variability | three months | Heart rate variability will be assessed through holter |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Oxygen consumption | three months | Oxygen consumption will be assessed through exercise test |
Countries
Brazil
Contacts
Primary ContactTUIRA O MAIA
Backup ContactPatrícia Erika M M
Outcome results
None listed