Osteoarthritis Of Knee
Conditions
Keywords
Osteoarthritis, Depression, Pain
Brief summary
By taking certain antidepressant in early postoperative period，which is supposed to improve the psychological status of patients with osteoarthritis, explore the effect of certain antidepressant on the recovery of the early stage after the operation of knee joint replacement.
Detailed description
In this study, the investigators are going to investigate the efficacy of Duloxetine on pain, physical function, mental health and quality of life in patients underwent TKAs. The control group is going to be given celecoxib 200mg/24h to 2 weeks after operation.On the basis of the above scheme, the treatment group is going to receiving duloxetine 60mg/24h to 8 weeks after operation.HAMD-17 scale, KSS scale, SF-36 scale and WOMAC scale will be used to evaluate the two groups before and after operation for 4 and 8 weeks.
Interventions
DRUGDuloxetine Hydrochloride
The treatment group will receive duloxetine 60mg/24h to 8 weeks after operation
Sponsors
Dalian Municipal Central Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
All patients will be randomly divided into two groups. The control group is going to be given celecoxib 200mg/24h to 2 weeks after operation. On the basis of the above scheme, the The treatment group will receive duloxetine 60mg/24h to 8 weeks after operation.
Eligibility
Sex/Gender
ALL
Age
51 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
1. No extra articular malformations are diagnosed and accord with Kellgren-Lawrence criteria 2. Primary TKA surgery,Varus is smaller than 20° 3. Always there is no history of mental illness, no history of relevant medicine 4. Be able to read and understand Chinese, with good communication skills 5. Voluntary participation in this clinical study
Exclusion criteria
1. Previous history of mental and psychological illness 2. With severe diseases in respiratory system, circulatory system or digestive system 3. Allergic to duloxetine and celecoxib
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain score of participants with Duloxetine as assessed by Western Ontario and McMaster Universities Index after 4 weeks of treatment. | up to 6 months | A face-to-face questionnaire will be conducted by two trained interviewers |
| Function score of participants with Duloxetine as assessed by Knee Society Score after 4 weeks of treatment. | up to 6 months | A face-to-face questionnaire will be conducted by two trained interviewers |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain score of participants with Duloxetine as assessed by Western Ontario and McMaster Universities Index after 8 weeks of treatment. | up to 6 months | A face-to-face questionnaire will be conducted by two trained interviewers |
| Function score of participants with Duloxetine as assessed by Knee Society Score after 8 weeks of treatment. | up to 6 months | A face-to-face questionnaire will be conducted by two trained interviewers |
Countries
China
Outcome results
None listed