Healthy
Conditions
Brief summary
The main aim of this project is to develop a new model to characterize brain connectivity and its changes with aging. This characterization will be based on new sensitive and specific markers, allowing a better understanding of structural and functional brain networks. To this end, two complementary MRI methods will be developed: 1) Resting-state functional MRI (rs-fMRI) which allows the measurement of cerebral activity in different cortical gray matter regions, and 2) high angular resolution diffusion imaging (HARDI) MRI, which allows to characterize brain tissue microarchitecture. HARDI sequences will be developed to acquire and reconstruct fiber tractography of patient's brains. In combination with conventional MRI, both HARDI and rs-fMRI will be used to estimate the connection degree between each pair of cortical regions, so- called Connectome. Once generated, brain networks will be quantified through numerous graph metrics, such as graph density, global efficiency and assortativity (etc.), reflecting the organization and topology of subjects' connectivity with aging.
Interventions
OTHERSingle complete MRI intervention
MRI examination will comprise conventional T1 and FLAIR sequences, and advanced sequences such as rs-fMRI and High angular resolution MRI (HARDI).
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Volunteers (Men and women) aged between 18 and 50 years * No neurological or psychiatric diseases
Exclusion criteria
* MRI contraindications * Pregnant women or nursing women * Persons under guardianship or any other administrative or deprivation of liberty or of right
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Functional and structural connectivity MRI marker : resting-state fMRI | End of study (one year) | Functional connectivity of grey matter (GM) using resting-state fMRI |
| Functional and structural connectivity MRI marker : Functional connectivity | End of study (one year) | Graph-theory methods analysis of functional connectivity of grey matter |
| Functional and structural connectivity MRI marker : Diffusion tensor | End of study (one year) | Structural connectivity of white matter (WM) fiber bundles measured by diffusion tensor imaging |
| Functional and structural connectivity MRI marker : Structural connectivity | End of study (one year) | Graph-theory methods analysis of Structural connectivity of white matter (WM) fiber |
| Functional and structural connectivity MRI marker : SPM software | End of study (one year) | Cortical and subcortical grey matter (GM) volumes using the SPM software |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Metrics of functional connectivity | End of study (one year) | Calculation of functional connectivity metrics using graphs theory methods |
Countries
France
Outcome results
None listed