PCOS
Conditions
Brief summary
L-carnitine and plus metformin in clomiphene-resistant obese PCOS women, reproductive and metabolic effect: a randomized clinical trial
Detailed description
the trial aims to compare L-carnitine and plus metformin in clomiphene-resistant obese PCOS women with placebo to state the reproductive and metabolic effects in form of pregnancy and insulin resistance parameters and lipid metabolism.
Interventions
DRUGL-carnitine and Metformin
L-carnitine plus Metformin was given Obese PCOS Women trying induction of ovulation with clomiphene citrate.
DRUGplacebo
placebo was given Obese PCOS Women trying induction of ovulation with clomiphene citrate.
Sponsors
Zagazig University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* pco * obese * ifertile
Exclusion criteria
* no medical disorders * no hormonal treatment in the previous 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| pregnancy rate | 3 momths | number of women with clinical pregnancy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| ovulation rate | 3 momths | number of women with follicle \>18mm. |
| abortion rate | 3 momths | number of women with abortions |
| insulin resistance | 3 momths | fasting glucose and insulin |
| lipid metabolism | 3 momths | Triglyceride, cholesterol |
Countries
Egypt
Outcome results
None listed