Multiple Sclerosis
Conditions
Brief summary
This study evaluates different optimized MRI sequences for the detection of brain lesions in patients with multiple sclerosis in comparison with the recommended FLAIR sequence
Detailed description
MRI is a tool of choice for detecting demyelinating lesions in Multiple Sclerosis (MS) disease. On a consensual basis, the detection of those lesions in done on FLAIR (FLuid Attenuated Inversion Recovery) sequences, weighted T2 with cancelling of fluid signal, leading to a much better contrast between the lesion and the environment. The environment is displayed as a iso-signal for the surrounding healthy brain's white matter and as a hypo-signal for the fluids. Keys parameters indicative of the sequence's contrast are the echo time, the reversal time, and the repetition time, wich seems to be crucial to detect the lesions, according to relatively discordant results of publications using different technologies of FLAIR. Although 3D FLAIR sequences play an essential role for diagnosis and evaluation (evolution under treatment, prognosis) of demyelinating pathologies there is no consensus on parameters used on routine basis. The aim of the trial is to discover the optimal combination of theses parameters so as to well detect the lesions.
Interventions
None listed
Sponsors
Fondation Ophtalmologique Adolphe de Rothschild
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* relapsing remitting multiple sclerosis * MRI required
Exclusion criteria
* MRI contraindication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of detectable lesions | baseline | quantification of lesions on each sequence |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| localisation of lesions | baseline | proportion of lesions localised in cerebellum or brainstem, on each sequence |
Outcome results
None listed