Perinatal Mortality, Premature Rupture of Fetal Membranes
Conditions
Keywords
predictive score
Brief summary
Pretern premature rupture of the membranes (PPROM) remains the leading cause of preterm deliveries and neonatal mortality and morbidity. PPROM is defined as rupture of the fetal membranes prior to 37 weeks' gestation. PPROM complicates 2-4% of all pregnancies and accounts for approximately 30 % of preterm births. The etiology of PPROM remains elusive. PPROM is one of the main causes of prematurity and its complications, such as newborn respiratory distress syndrome, neonatal sepsis, necrotizing enterocolitis, intraventricular hemorrhage, perventricular leucomalacia, varying degrees of lung hypoplasia and bronchopulmonary dysplasia. All these factors contribute greatly to an increase in neonatal morbidity and mortality Management of PPROM followed actual guidelines. Conservative management to prolong a pregnancy is a classical approach to treat PPROM before 34 weeks' gestation in association with antibiotic therapy and corticosteroids. Maternal and neonatal data were collected from maternal and newborns medical records.
Interventions
OTHERValidation of a diagnostic test
Validation of a diagnostic test
Sponsors
Centre Hospitalier Universitaire, Amiens
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* Women with PPROM between 22 weeks and 27 weeks and 6 days are eligible for this study
Exclusion criteria
* Therapeutic abortion / terminaison of pregnancy * Intra uterine demise * active labor with cervical dilatation of 3 cm with regular contractions. * Triplet pregnancies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The purpose was to determine which antepartum criteria were efficient to predict neonatal death, in order to create a predictive prognostic antenatal index of mortality. | 1 day |
Countries
France
Outcome results
None listed