Renal Transplant
Conditions
Brief summary
Renal transplantation is now recognized as a treatment of choice for patients with chronic renal failure with end-stage renal disease. Renal transplantations are associated with better quality of life, better cost/benefit ratio, and possibly longer survival. Significant changes in blood pressure are common throughout the surgical procedure for kidney transplantation. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration.
Interventions
DRUGNorepinephrine
Norepinephrine infusion will be used at a starting dose of 0.05μg/kg/min. Dose range: 0.05 -0.15 μg/kg/min. Infusion will be started with arterial decamping and continues till 24 hours postoperative
DRUGDopamine
Dopamine infusion will be used at a starting dose of 5μg/kg/min. Dose range: 5 -15 μg/kg/min. Infusion will be started with arterial decamping and continues till 24 hours postoperative
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Patients scheduled for a living donor kidney transplantation
Exclusion criteria
* Patients (less than 18 years old) * Patients' refusal of consenting for enrolment in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| serum creatinine | four hours postoperatively | postoperative |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| renal artery blood flow | four hours postoperatively | Measured postoperative through renal artery Doppler |
| blood urea | four hours postoperatively | postoperative |
| urine output | over 24 hours | postoperative |
| renal artery diameter | four hours postoperatively | Measured postoperative through renal artery Doppler |
Countries
Egypt
Contacts
Primary ContactAhmed Elkadi, MBBC
Outcome results
None listed