Clinical Presentations Before AMI Onset and Coronary Atherosclerosis

Pre-infarction Angina and Culprit Plaque Characteristics in Patients With STEMI

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03107624

Enrollment

305

Registered

2017-04-11

Start date

2016-06-01

Completion date

2017-06-01

Last updated

2019-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Myocardial Infarction

Brief summary

This study aimed to evaluate the incidence of preinfarction angina in AMI patients and test the hypothesis that different clinical presentations before AMI onset can affect coronary plaque morphologies in AMI patients .

Detailed description

Patients with AMI who underwent primary percutaneous coronary intervention（PCI） and optical coherence tomography (OCT) examination is expected to be included in this study.Data about history were prospectively collected by a standard questionaire ,especially regarding the detail information about preinfarction angina.The basic clinical characteristics,angiographic and OCT findings are compared between patients with and without preinfarction angina.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

： 1. Men or non-pregnant women \>18 years of age and \< 85 years of age; 2. Patients undergo cardiac catheterization for AMI; 3. Patients able to provide written informed consent.

Exclusion criteria

1. Patients cant afford medical history; 2. Cardiac shock； 3. Severe left ventricular dysfunction; 4. Left main disease; 5. Hepatic or kidney dysfunction; 6. OCT was performed after predilation; 7. Poor OCT image or massive thrombus.

Design outcomes

Primary

Measure	Time frame	Description
Difference in culprit lesion morphologies assessed by OCT according to the presence or absence of PIA	baseline	Plaque rupture was defined by the presence of a cavity formation in the plaque with a discontinuity of the fibrous cap. TCFA was defined as a lipid-rich plaque with a thin fibrous cap thickness of ≤ 65 um.Thrombus was identified by OCT as an irregular mass ≧0.25 mm in diameter protruding into the vessel lumen or attached to the surface of the vessel wall.Culprit lesion features in patients with PIA show a lower incidence of plaque rupture and TCFA compared to those without PIA.

Secondary

Measure	Time frame	Description
In-hospital outcomes after AMI.	baseline	Infarct size was measured as the peak cardiac troponin I (cTnI) level.PIA is associated with lower infarct size and lower in-hospital mortality.

Countries

China

Outcome results