Debility Due to Disease, Sarcopenia
Conditions
Brief summary
Skeletal muscle abnormalities (sarcopenia) and frailty are common complications seen in patients with end-stage liver disease. The presence of these complications portends poor prognosis. The purpose of this study is to assess the impact of a formal home based video strengthening program (REST) on sarcopenia and frailty. We also want to assess the impact of this exercise program on complication rates, hospitalization, on quality of life (QOL) and on survival.
Interventions
BEHAVIORALexercise
home exercise program
OTHERplacebo
encourage walking and physical therapy per standard care.
Sponsors
Mayo Clinic
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
home exercise vs standard care with cross-over
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
inclusion= waitlisted for liver transplant with poor 6MWT
Exclusion criteria
include: age \< 18 years, recent hospitalization (within 14 days) due to decompensation, variceal bleeding in the previous 1 month, large esophageal varices without primary prophylaxis, active excessive alcohol intake (in the previous 3 months), current overt uncontrolled hepatic encephalopathy, hepatopulmonary syndrome with uncontrolled hypoxia, portopulmonary hypertension, inability to perform exercise, or marked symptomatic comorbidities (cardiac, pulmonary, renal). multiorgan transplant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 6MWT | 3 months | 6 minute walk |
| hand grip | 3 months | hand grip |
Countries
United States
Outcome results
None listed