Inflammation of the Eyelids
Conditions
Brief summary
The study aims to investigate the effect of Permethrin 5% treatment on Signs and symptoms of Demodex-blepharitis in comparison to Synthomycine 5% and Fucithalmic (fusidic acid 1%) .
Detailed description
3 arms study. 75 patient total, 25 patients in each group. Group A (study group) patients will apply facially Permethrin 5% every night for 3 months. Group B patients will apply on the eyelids Fusidic acid 1% every night for 3 months. Group C patients will apply on the eyelids Synthomycine 5% every night for 3 months Follow up Evaluation will be made after one week, one month, two months, three months, 4 months and half a year.
Interventions
DRUGPermethrin 5%
Facial skin application once a night for 3 months.
DRUGSynthomycine 5%
Eye ointment, eyelids and eyelashes application (chloramphenicol), once a night for 3 months.
DRUGFusidic Acid 1% M/R Eye Drops
viscous eye drops application once a night for 3 months.
Sponsors
Barzilai Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- Adult (Age ≥18Y) individuals clinically diagnosed with Demodex- blepharitis.
Exclusion criteria
\- Known sensitivity to all study medications or components. Pregnant women and individuals deemed unfit to provide informed consent. Systemic steroid use.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Decrease in demodex infestation in group A (permethrin 5%). | 2 months | significant decrease in demodex infestation in comparison to group B and C. |
| Improvement in symptoms and complaints in group A. | 2 months | OSDI Questionnaires that describe the severity of the ocular surface disease condition are filled in each visit. |
Countries
Israel
Outcome results
None listed