Depression
Conditions
Keywords
electroconvulsive therapy, anaesthesia
Brief summary
This study will examine how anaesthetic technique affects ECT outcomes. Specifically, the investigators will examine how: 1) the time interval between anaesthetic and ECT stimulus, and 2) the ventilation rate before ECT stimulus, impacts on the quality of the EEG (this is a recording of brain activity during ECT and is used to judge the quality of a seizure and to guide individual patient dosing).
Detailed description
This study aims to examine how the time interval between administration of anaesthetic agent and ECT stimulus delivery impacts upon measures of EEG quality (seizure quality).
Interventions
OTHERElectroconvulsive Therapy (ECT) time interval + Anaesthetic (Thiopentone)
The intervention in this study is the time interval between anaesthetic administration and ECT stimulus
Sponsors
Wesley Mission
The University of New South Wales
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
Both participants and the outcome assessor (analysing EEGs) will be blinded.
Intervention model description
Each participant will receive all four treatment conditions in randomly allocated sequence during their ECT course. That is, participants will receive either short or long anaesthetic-ECT stimulus time interval treatments, and normal or hyperventilation treatments - this results in four possible combinations, which individual participants will cycle through in random order during their ECT course (e.g. short-hyperventilation, long-normal ventilation, short-normal ventilation, long-hyperventilation).
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients treated with a course of ECT
Exclusion criteria
* Use of non-standard anaesthetic agents in ECT (e.g. ketamine)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| EEG Seizure Quality Rating using the EEG Seizure Quality Rating Sheet utilised by MacPherson et al | Outcome measures will be collected immediately after each ECT treatment from the first treatment until the end of the ECT course, an estimated total of four to six weeks for most participants | EEG quality will be rated manually for each ECT treatment undertaken by a participant until the conclusion of their ECT course. This rating will be done using the EEG Seizure Quality Rating Sheet utilised by MacPherson et al - low dose lignocaine added to propofol does not attenuate the response to electroconvulsive therapy; Journal of Affective Disorders, 2010; 126: 330-333 |
Countries
Australia
Outcome results
None listed