Open Heart Surgery, Preconditioning
Conditions
Brief summary
preconditioning of no debate has a valuable effect upon myocardial protection . pre-cardiopulmonary bypass pre-conditioning , suspected to have a role upon postoperative inotropic support
Detailed description
Preconditioning (PC) of the heart occurs when brief exposure to a stimulus protects the heart from subsequent ischemia. PC stimulus may be ( ischemic ;pharmacologic or Physical) Pharmacological pc may be induced by variable agents e.g. (Sevoflurane ;isoflorane, opioids etc ) Ischemic pc includes local ;remote and the idea is temporary interruption of blood supply to the organ so that liberation of protective mediators occurs The liberated mediators have favorable effects not only upon the myocardium But ;it extend to protect other organs against inflammatory activation ;ischemia reperfusion injury Inotropic score IS is already an evident predictor of postoperative cardiac mobidity and mortality
Interventions
PROCEDUREischemic preconditioning
) ischemic preconditioning will be done after induction and before cardiopulmonary bypass by inflation the cuff of blood pressure above 200mmhg in the lower limb every 5 min for 3cycles
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
16 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* adult patient * valve replacement surgery * ASA grade 2 or 3
Exclusion criteria
* emergency surgery * \- poor general conditions * impaired hepatic or renal function * peripheral vascular disease * patient refusal
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| inotropic score | 48 hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| renal function | 2 dyas | serum creatinine |
Countries
Egypt
Outcome results
None listed