Cannabis Dependence, Healthy
Conditions
Keywords
Healthy Control, Cannabis, Dependence
Brief summary
The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed abstinence. This research will also examine associations between CB1R availability, neural oscillations and cognitive function.
Detailed description
The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed outpatient abstinence (confirmed by tracking creatinine adjusted urine THC-COOH levels). This research will also examine associations between CB1R availability, neural oscillations and cognitive function using \[11-C\]OMAR PET imaging and electroencephalography.
Interventions
DRUG[11-C]OMAR
The radiotracer, \[11-C\]OMAR will be administered at no more than 10 micrograms at the beginning of each PET scan.
Sponsors
National Institute on Drug Abuse (NIDA)
Yale University
Study design
Observational model
OTHER
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
Cannabis Dependent Subjects * Current cannabis consumption * Willing to abstain from cannabis use for four weeks Inclusion Criteria for Healthy Controls * No current cannabis consumption
Exclusion criteria
* MRI metal exclusions and claustrophobia * Education completed is less than 12 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| CB1R availability using [11-C]OMAR PET imaging | Change in CB1R availability from baseline to 48 hours and 28 days | Change in CB1R availability (e.g. volume distribution). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Cognition during withdrawal using a computerized battery | Change in CB1R availability from baseline to 48 hours and 28 days | Changes in cognitive functions such as attention, memory, motor functioning, and processing speed. |
| Changes in brain rhythms measured by Electroencephalography | Change in CB1R availability from baseline to 48 hours and 28 days | Changes in electroencephalographic (EEG) brain rhythms related to information processing. |
Countries
United States
Outcome results
None listed