Epilepsy
Conditions
Brief summary
Exploring the reorganization (plasticity) of neuroanatomic networks associated with language and memory in patients with left (or dominant hemisphere) temporal lobe epilepsy using functional MRI (fMRI)
Detailed description
The purpose of this study is to explore the reorganization of neuroanatomic networks associated with language and memory in adult patients with temporal lobe epilepsy (ELT). By using functional MRI, patients will be examined before and after surgery. Cerebral plasticity, defined in terms of intrinsic variables such as the topography of the activated regions, will be explored according to some extrinsic factors such as the age at onset of crises (before or after 5-6 years), whether or not Hippocampal sclerosis, hemispheric predominance of language (left or right).
Interventions
OTHERfunctional MRI
Sponsors
Laboratoire de Psychologie et NeuroCognition
University Hospital, Grenoble
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
2 arms : epileptic patient and healthy volonteers
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* epileptic patients * medical exam before inclusion * social security affiliation * Pharmaco-resistant epilepsy
Exclusion criteria
* MRI contraindication * pregnant women * breastfeeding mothers * person under tutorship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| neuronal reorganization exploration in language and memory area thanks to functionnal MRI | one hour for each exam | fMRI exam before and after resection surgery of epileptogenic area: assess (plasticity) of neuroanatomic networks associated with language and memory - examined before and after surgery |
Outcome results
None listed