Muscle Loss
Conditions
Keywords
FFM, VLCD, exercise, Protein, Obesity
Brief summary
In this study, we aimed to examine the effect of whey protein supplementation given before night sleep on Fat Free Mass (FFM) preservation during a 4 wk period on Very Low Caloric Diet (VLCD). Half of the participants underwent a 4 week VLCD and walking program, while the other half underwent a 4 week VLCD, walking program and had an additional protein supplement before each night sleep.
Interventions
Sponsors
Orkla Health
Toyota-Fonden
Tømmerhandler Vilhelm Bangs Fond
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Masking description
Single blinded
Intervention model description
Randomized single blinded, controlled intervention trial
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Body Mass Index (kg/m\^2) \> 28 * Age between 18 and 55 years
Exclusion criteria
* Participation in regular resistance-, aerobic- or anaerobic training (\>1 h/wk within the last 3 month before intervention start) * Diabetes Physical disabilities that would hinder completion of the walking program.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fat Free Mass | Change from baseline to after the 4 week intervention period | Dual energy X-ray absorptiometry (DXA) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Oral glucose tolerance test | Change from baseline to after the 4 week intervention period | OGTT |
| Fitness level | Change from baseline to after the 4 week intervention period | Bike test |
| Blood pressure | Change from baseline to after the 4 week intervention period | Blood pressure at rest |
| Nitrogen balance | Change in nitrogen content from baseline to day 7 and 28 of the intervention period | Three 24 hours urin samples |
| waist circumference | Change from baseline to after the 4 week intervention period | waist circumference |
| Performance test | Change from baseline to after the 4 week intervention period | Intermittent running test (YY1R1C) |
| Fat mass | Change from baseline to after the 4 week intervention period | DXA |
Outcome results
None listed