Liver Transplant; Complications
Conditions
Brief summary
The investigators investigated in the present study whether selective head cooling and dexmedetomidine has an effect on cerebral oxygenation during liver transplantation and has cerebral protective effect in patients undergoing liver transplantation.
Interventions
DRUGDexmedetomidine
Using dexmedetomidine at anesthesia induction and maintain until the end of the surgery
DEVICECooling Helmet
Using cooling helmet for selective head cooling group and Selective Head Cooling and Dexmedetomidine group
Sponsors
Huazhong University of Science and Technology
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Scheduled for OLT, selected from the Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China. * Sign the informed consent
Exclusion criteria
* The patients with a history of neurological or psychiatric disorders which impair cognitive processes, including previously established de-mentia, stroke, schizophrenia and depression were excluded from the study. * Patients diagnosed with hepatic encephalopathy or had a low Mini-Mental State Examination (MMSE) score (below 24) preoperatively. * With concurrent diseases such as renal insufficiency, diabetes mellitus were also excluded. * Patients were excluded if severe reperfusion syn-drome (mean arterial pressure below 60mmHg sustained over 15minutes) occurred perioperatively.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative minimal hepatic encephalopathy (MHE) | 14 days after surgery | Using PSE-Syndrom-Test |
Countries
China
Contacts
Primary ContactAilin Luo, doctorate
Outcome results
None listed